JOURNAL SPOTLIGHT

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Prognostic Value of Early Left Ventricular Ejection Fraction Reserve​ During Regadenoson Stress Solid-State SPECT MPI​

Yuka Otaki, Mathews B. Fish, Robert J. H. Miller, Mark Lemley, and Piotr J. Slomka

The recent emergence of solid-state SPECT camera systems resulted in significant improvements in count sensitivity and diagnostic accuracy for CAD allowing shorter acquisition times to facilitate early post-stress imaging. In the current study,  group sought to establish if early post-stress EF reserve or change in end-systolic volume (ESV) and end-diastolic volume (EDV), measured using solid-state SPECT MPI, is associated with major adverse cardiac events (MACE).

Early Post-Regadenoson Stress Solid-state SPECT MPI Protocol. Rest and stress 1-day 99mTc-sestamibi imaging was performed using high -efficiency, solid-state SPECT camera system (D-SPECT, Spectrum-Dynamics, Haifa, Israel)

Conclusion:

This is the first study to evaluate the utility of early post-stress imaging for MACE on vasodilator stress solid-state SPECT MPI.

Ejection fraction reserve, ∆ EDV, and ESV measured after early post-stress by solid-state SPECT MPI provide significant, independent, and incremental value for predicting the risk of adverse cardiovascular events. The measurement of LVEF reserve is possible using a solid-state SPECT system and prospective validation of the potential value of this information is warranted.

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